CLINICAL AND EXPERIMENTAL OBSERVATIONS ON FOCAL INFECTION, WITH AN ANALYSIS OF 200 CASES OF RHEUMATOID ARTHRITIS

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Article1 November 1938CLINICAL AND EXPERIMENTAL OBSERVATIONS ON FOCAL INFECTION, WITH AN ANALYSIS OF 200 CASES OF RHEUMATOID ARTHRITISRUSSELL L. CECIL, M.D., F.A.C.P., D. MURRAY ANGEVINE, M.D.RUSSELL L. CECIL, M.D., F.A.C.P., D. MURRAY ANGEVINE, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-5-577 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFocal infection is a splendid example of a plausible medical theory which is in danger of being converted by its too enthusiastic supporters into the status of an accepted fact. Certainly the theory of focal infection has travelled a long way since it was first presented to the medical profession of America by Frank Billings1in his classic contribution, "Chronic Focal Infections and Their Etiological Relations to Arthritis and Nephritis." This article was published in the Archives of Internal Medicine in 1912 and marks the first important contribution to the subject in this country. Today, 25 years after publication of...Bibliography1. BILLINGS F: Chronic focal infections and their etiologic relations to arthritis and nephritis, Arch. Int. Med., 1912, ix, 484. CrossrefGoogle Scholar2. CECILARCHER RLBH: Chronic infectious arthritis; analysis of 200 cases, Am. Jr. Med. Sci., 1927, clxxiii, 258. Google Scholar3. KRAUSEWILLIS AKHS: The rate of dissemination of virulent tubercle bacilli in normal and immune guinea pigs, Tubercle, 1924, vi, 438. Google Scholar4. WILLIS HS: Studies on tuberculous infection. X. The early dissemination of tubercle bacilli after intracutaneous inoculation of guinea pigs of first infection, Am. Rev. Tuberc., 1925, xi, 427. Google Scholar5. FREUND J: Retardation of tuberculous infection in guinea pigs vaccinated with killed tubercle bacilli as shown by cultural method, Proc. Soc. Exper. Biol. and Med., 1932, xxix, 1200. CrossrefGoogle Scholar6. ANGEVINE DM: The fate of avirulent hemolytic streptococci injected into the skin of normal and sensitized rabbits, Jr. Exper. Med., 1934, lx, 269. CrossrefGoogle Scholar7. ANGEVINE DM: The fate of a virulent hemolytic streptococcus injected into the skin of normal and immunized rabbits, Jr. Exper. Med., 1936, lxiv, 131. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Read before the American College of Physicians, New York, N. Y., April 4, 1938.From the Departments of Medicine and Pathology of New York Hospital and Cornell University Medical College, New York City.Aided by a grant from the John and Mary R. Markle and the Ophthalmological Foundations. 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