PubMed · 1982 · 555 citations · 0 references
Health ProfessionsClinical SciencesPhysiologyExercise TestingPulmonary Function TestingPulmonologyDiffusing CapacityForced Vital CapacityLung VolumesPulmonary AssessmentPulmonary Function AssessmentPulmonary MechanicsHelium Dilution TestingLinear RegressionLung CapacitiesLung Volume EstimationMultiple RegressionPredicted Lung VolumesResidual Capacity AssessmentSpirometric Lung Volumes
The study measured total lung capacity, functional residual capacity, and residual volume in 245 healthy nonsmoking adults using a single‑breath helium dilution technique and derived prediction equations by multiple linear regression. The resulting equations closely match those from multiple‑breath gas equilibration methods, with 95 % confidence intervals accurately approximated by twice the standard error rather than ±20 % of the predicted value, and radiographic TLC did not differ significantly from helium dilution TLC.
Total lung capacity (TLC), functional residual capacity, residual volume, and corresponding 95% confidence intervals were measured in 245 healthy nonsmoking person (122 women, 123 men) using a single-breath helium technique. Prediction equations for lung volumes were generated by multiple linear regression. The resultant equations are similar to previously published equations using multiple-breath gas equilibration techniques. Measured 95% confidence intervals can be closely approximated by using two times the standard error of the estimate for each equation, but cannot be approximated by using +/- 20% of the predicted value. Radiographic TLC was not significantly different from the helium dilution TLC.