MULTICENTER PHASE II RANDOMIZED STUDY EVALUATING DOSE–RESPONSE OF ANTIPERISTALTIC EFFECT OF L‐MENTHOL SPRAYED ONTO THE GASTRIC MUCOSA FOR UPPER GASTROINTESTINAL ENDOSCOPY

Abstract

L-menthol suppresses peristalsis in a dose-dependent manner, and the dose-response reaches a plateau at 0.8% L-menthol. Further Phase III studies are needed to establish the superiority of 0.8% L-menthol over placebo.