Inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by mevinolin.

Abstract

Mevinolin is demonstrated to inhibit the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in Chinese hamster ovary cells. Evidence is presented that this effect of mevinolin is not general to degradation of total cellular proteins and is not due to the block to mevalonate synthesis produced by this compound.