Intra-articularly localized bacterial DNA containing CpG motifs induces arthritis

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

Samuel D. Wright, Robert Ramos, Peter S. Tobias et al. · Science · 1990 · 4K citations

Life Sciences, Biochemistry, Immunology +16

CpG motifs in bacterial DNA trigger direct B-cell activation

Arthur Μ. Krieg, Ae‐Kyung Yi, Sara Matson et al. · Nature · 1995 · 3.5K citations

Life Sciences, Microbiology, Molecular Biology +10

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.

Dennis M. Klinman, Ae‐Kyung Yi, Serge L. Beaucage et al. · Proceedings of the National Academy of Sciences · 1996 · 1.5K citations

Life Sciences, Immunology, Microbiology +17

Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.

Richard Williams, Marc Feldmann, R N Maini · Proceedings of the National Academy of Sciences · 1992 · 986 citations

Medicine, Immunology, Pathobiology +12

CpG Motifs in Bacterial DNA Activate Leukocytes Through the pH-Dependent Generation of Reactive Oxygen Species

Ae-Kyung Yi, Rebecca Tuetken, Thomas W. Redford et al. · The Journal of Immunology · 1998 · 330 citations · Full text

Life Sciences, Cell Biology, Immunology +14