Anti‐arthritis effects of (E)‐2,4‐bis(<i>p</i>‐hydroxyphenyl)‐2‐butenal are mediated by inhibition of the <scp>STAT3</scp> pathway

Abstract

(E)-2,4-bis(p-hydroxyphenyl)-2-butenal exerted anti-inflammatory and anti-arthritic effects through inhibition of the NF-κB/STAT3 pathway by direct binding to STAT3. This compound could be a useful agent for the treatment of arthritic disease.