Antidepressant‐like effect induced by systemic and intra‐hippocampal administration of DNA methylation inhibitors

Abstract

Systemic, as well as hippocampal, inhibition of DNA methylation induced antidepressant-like effects. These effects could be associated with increased hippocampal expression of BDNF. Our data give further support to the hypothesis that DNA methylation is an important epigenetic mechanism involved in the development of depressive-like behaviours.