The non‐peptide<scp>GLP</scp>‐1 receptor agonist<scp>WB</scp>4‐24 blocks inflammatory nociception by stimulating<scp>β</scp>‐endorphin release from spinal microglia

Abstract

Our results suggest that WB4-24 inhibits inflammatory nociception by releasing analgesic β-endorphin rather than inhibiting the expression of proalgesic pro-inflammatory cytokines in spinal microglia, and that the spinal GLP-1 receptor is a potential target molecule for the treatment of pain hypersensitivity including inflammatory nociception.