Use of Intravital Microscopy to Study the Microvascular Behavior of Microbubble‐Based Ultrasound Contrast Agents

Abstract

These results support the safety of both targeted and nontargeted UCAs as no microvascular flow alteration or plugging of microvessels were observed. They confirm that binding observed with targeted microbubbles are due to the binding of these microbubbles to specific endothelial receptors.