Southern Medical Journal · 2004 · 29 citations · 2 references
MedicineHematologyOncologyChemotherapyHematologic OncologyHematopathologyAnemiaMyelodysplastic SyndromesVitamin B12 DeficiencyVitamin B12 PhysiologyVitamin PhysiologyVitamin SupplementationBone Marrow AssessmentPernicious Anemia Differential DiagnosisVitamin B12 (Cobalamin)Vitamin B12 Deficiency AnemiaVitamin B12 Deficiency PhysiologyVitamin B12 Deficiency TreatmentVitamin B12 Metabolism
Vitamin B12 deficiency can cause profound alterations in the bone marrow. These alterations can mimic the more serious diagnosis of acute leukemia. The two patients described in this report were originally suspected of having acute leukemia or myelodysplasia on the basis of the bone marrow smear, and induction chemotherapy was considered. However, after further studies, they were both found to have vitamin B12 deficiency, and parenteral vitamin B12 administration resulted in normalization of the bone marrow.
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Vitamin B-12 and folate deficiency presenting as leukaemia.
Inderjeet Dokal, Timothy M. Cox, D. A. G. Galton · BMJ · 1990 · 20 citations · Full text