Influence of β‐adrenoceptor antagonists on the pharmacokinetics of rizatriptan, a 5‐HT_1B/1D agonist: differential effects of propranolol, nadolol and metoprolol

Abstract

These results suggest that propranolol increases plasma concentrations of rizatriptan by inhibiting monoamine oxidase-A. When prescribing rizatriptan to migraine patients receiving propranolol for prophylaxis, the 5 mg dose of rizatriptan is recommended. Administration with other beta-adrenoceptor blockers does not require consideration of a dose adjustment.