The International Journal of Artificial Organs · 1991 · 22 citations · 10 references
The migration of plasticizers from blood lines was studied in 11 patients with chronic renal failure on hemodialysis for a period of six months. Di-2-ethylhexylphthalate (DEHP), the conventional plasticizer, was compared with tri-2-ethylhexyltrimellitate (TEHTM). A liquid chromatography method for quantitative determination of DEHP and TEHTM in human blood plasma is described. During treatment with tubing containing DEHP, the plasma level of DEHP rose from 0.10 micrograms/ml (less than 0.05-0.17 n = 11) to 0.70 micrograms/ml (0.30-1.6 n = 11). When the patients were changed to tubing containing TEHTM, the concentration of DEHP was below or close to the detection limit and TEHTM could not be detected. No adverse events of either tubing were found as regards acute toxic effects, performance or applicability.
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Bis(2-ethylhexyl)phthalate concentrations in the serum of hemodialysis patients.
L Lewis, T W Flechtner, Julius Kerkay et al. · Clinical Chemistry · 1978 · 62 citations
Leachability of a new plasticizer tri-(2-ethylhexyl)-trimellitate from haemodialysis tubing.
L. Flaminio, L De Angelis, M Ferazza et al. · PubMed · 1988 · 43 citations