Journal of Cellular Physiology · 2013 · 60 citations · 17 references
MedicineOncologyUrologyGene ExpressionMolecular OncologyTumor ProgressionBiomarkers In Genitourinary CancerBiomarkers In Urologic OncologyMolecular Tumor ProfilingProstate CancerProstate PathologyProstatic PathologyEarly DiagnosisGleason ScoringMicrorna Prognostic MarkersNeuroendocrine Cell DifferentiationNeuroendocrine DifferentiationProstate Cancer PrognosisRecurrenceTumor Biomarker Discovery
Castration-resistant prostate cancer (CRPC) and its treatment are challenging issues in prostate cancer management. Here, we report that miR-663 is upregulated in CRPC tissues. Overexpression of miR-663 in prostate LNCaP cells promotes cell proliferation and invasion, neuroendocrine differentiation, and reduction in dihydrotestosterone-induced upregulation of prostate-specific antigen expression. Furthermore, results of in situ hybridization show that miR-663 expression is correlated with Gleason score and TNM stage and is an independent prognostic predictor of clinical recurrence. Together, these findings suggest that miR-663 is a potential oncomiR for CRPC and may serve as a tumor biomarker for the early diagnosis of CRPC.
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MicroRNA Expression Profiling in Prostate Cancer
Minja J. Pfeiffer, Kati K. Waltering, Robert L. Vessella et al. · Cancer Research · 2007 · 905 citations