BMC Infectious Diseases · 2006 · 100 citations · 24 references
Life SciencesGeneticsImmunologyGenetic EpidemiologyImmunogeneticsMedical GeneticsAcute Respiratory Distress SyndromeAntiviral ImmunityCytokine BiologyCytokine Gene PolymorphismGenetic SusceptibilityInterleukin Gene VariantsAntiviral Mechanisms Of ActionCase-control Study DesignGenotype DistributionInterferon Gene PolymorphismsInterferon Gene VariantsInterferon Receptor PolymorphismsInterleukin-10 Gene VariantsSevere Acute Respiratory Syndrome
BACKGROUND: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-gamma,TNF-alpha and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). METHODS: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-gamma,TNF-alpha and IL-10 for their associations with SARS. RESULTS: IFN-gamma +874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-gamma +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-alpha were not associated with SARS susceptibility. CONCLUSION: IFN-gamma +874A allele was shown to be a risk factor in SARS susceptibility.
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Coronavirus as a possible cause of severe acute respiratory syndrome
ST Lai, Yi Guan, Lyc Yam et al. · The Lancet · 2003 · 3K citations · Full text
AN INVESTIGATION OF POLYMORPHISM IN THE INTERLEUKIN‐10 GENE PROMOTER
David M. Turner, Denise Williams, David Sankaran et al. · European Journal of Immunogenetics · 1997 · 1.7K citations
Life Sciences, Genetics, Immunology +14