Piperacillin‐Tazobactam Pharmacokinetics in Patients With Intraabdominal Infections

Abstract

Our findings were similar to those in other surgical patient models. The two-compartmental model best described piperacillin and tazobactam disposition in our patients. Bayesian analyses of the two-compartment models of piperacillin and tazobactam were able to predict trough, peak, and 2-hour postadministration levels without bias.