Studies on an Antibiotic, Albocycline. V. High Pressure-High Temperature Hydrogenation Products, and Structure Proof of Albocycline

Abstract

By the catalytic hydrogenation of albocycline in acetic acid under high pressure at elevated temperature, nine reaction products were obtained. They were classified into pairs by their infrared (IR), nuclear magnetic resonance (NMR) and mass spectral data. The eluci dation of structures of these pair products gave the conclusive answers about the positions of O-functions, especially that of a methoxy group, in albocycline molecule. Thus, the structure of albocycline was finally confirmed as Ia.