Elucidation of the molecular mechanism and the efficacy<i>in vivo</i>of a novel 1,4‐benzoquinone that inhibits 5‐lipoxygenase

Abstract

RF-Id represents a novel anti-inflammatory 1,4-benzoquinone that potently suppresses LT biosynthesis by direct inhibition of 5-LOX with effectiveness in vivo. Mechanistically, RF-Id inhibits 5-LOX in a non-redox manner by forming discrete molecular interactions within the active site of 5-LOX.