Molecular modelling studies, synthesis and biological activity of a series of novel bisnaphthalimides and their development as new DNA topoisomerase II inhibitors

Rosanna Filosa, Antonella Peduto, Simone Di Micco, +5

Bioorganic & Medicinal Chemistry

Biological ActivityCombinatorial ChemistryMedicinal ChemistryBioorganic ChemistryBiochemistry +10

Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin

Anja Schaible, Heidi Traber, Veronika Temml, +7

Biochemical Pharmacology

Anti-inflammatory Agent EmbelinMedicineLipid PeroxidationPotent InhibitionAnti-cancer Agent +5

Evaluation of alternative strategies to optimize ketorolac transdermal delivery

Carmelo Puglia, Rosanna Filosa, Antonella Peduto, +4

AAPS PharmSciTech

Topical DrugSurgeryDrug Delivery SystemDelivery SystemKetorolac Transdermal Delivery

Hyperpipecolic acidaemia: a diagnostic tool for peroxisomal disorders

Antonella Peduto, Matthias R. Baumgartner, Nanda M. Verhoeven, +7

Molecular Genetics and Metabolism

Hyperpipecolic AcidaemiaPathologyLaboratory MedicineChemical PathologyMedicine +1

Synthesis and Reactivity of the 3‐Substituted Isoindolinone Framework to Assemble Highly Functionalized Related Structures

Carmen Petronzi, Selene Collarile, Gianluca Croce, +7

European Journal of Organic Chemistry

Combinatorial ChemistryChemical EngineeringEfficient PotassiumEngineeringNovel Organocatalysts +13

Structure–activity relationship study of arbidol derivatives as inhibitors of chikungunya virus replication

Antonia Di Mola, Antonella Peduto, Annalisa La Gatta, +6

Bioorganic & Medicinal Chemistry

BiochemistryChikungunya Virus ReplicationStructure–activity Relationship StudyMedicineAntiviral Drug Development +7

Design of inhibitors of influenza virus membrane fusion: Synthesis, structure–activity relationship and in vitro antiviral activity of a novel indole series

Virginia Brancato, Antonella Peduto, Stephen A. Wharton, +11

Antiviral Research

Structure–activity RelationshipVirus StructureVitro Antiviral ActivitySynthetic VirologyMedicine +8

Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based ω-acidic amino acids as glutamate receptors ligands

Rosanna Filosa, Maria Carmela Fulco, Maura Marinozzi, +8

Bioorganic & Medicinal Chemistry

BiochemistryFunctional SelectivityMedicineNovel BicycloBiological Evaluation +4

Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase

Rosanna Filosa, Antonella Peduto, Polamarasetty Aparoy, +8

European Journal of Medicinal Chemistry

Bioorganic ChemistryChemoprevention StrategyBiochemistryAldehyde DehydrogenaseMedicine +7

Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes

Rosanna Filosa, Antonella Peduto, Anja Schaible, +10

European Journal of Medicinal Chemistry

OxysterolNovel SeriesBiochemistryHigh PotencyMedicine +6