A <scp><i>TREM</i></scp><i>1</i> variant alters the accumulation of Alzheimer‐related amyloid pathology

Abstract

We provide evidence that 2 common variants within the TREM locus are associated with pathological features of AD and aging-related cognitive decline. Our evidence suggests that these variants are likely to be independent of known AD variants and that they may work through an alteration of myeloid cell function.