Class E Thy-1 negative mouse lymphoma cells utilize an alternate pathway of oligosaccharide processing to synthesize complex-type oligosaccharides.

Abstract

Class E Thy-l negative mouse lymphoma cells have a block in the synthesis of the usual (Glc)o(Man)9-(G~cNAc)~ lipid-linked oligosaccharide and make, instead, a truncated molecule with the structure: Man al6 \ ' Man B1,4(3!GlcNAc /31,4(3) -GlcNAc 192 193 193 al,2 al,2 / Glc -+ Glc --B Glc -Man --+ Man + Man al,3