The chromosome make-up of mouse embryonic stem cells is predictive of somatic and germ cell chimaerism

Establishment in culture of pluripotential cells from mouse embryos

Martin Evans, M. H. Kaufman · Nature · 1981 · 8.6K citations

Life Sciences, Cell Biology, Developmental Biology +14

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.

Gail R. Martin · Proceedings of the National Academy of Sciences · 1981 · 5.7K citations

Life Sciences, Cell Biology, Developmental Biology +16

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

Kirk R. Thomas, Mario R. Capecchi · Cell · 1987 · 2.4K citations

Life Sciences, Developmental Biology, Molecular Biology +12

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

András Nagy, Janet Rossant, Roland Nagy et al. · Proceedings of the National Academy of Sciences · 1993 · 2.4K citations

Life Sciences, Biology, Genetics +16

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

Suzanne L. Mansour, Kirk R. Thomas, Mario R. Capecchi · Nature · 1988 · 1.7K citations

Medicine, Genetics, Molecular Genetics +15