The purinergic receptor P2Y₂receptor mediates chemotaxis of dendritic cells and eosinophils in allergic lung inflammation

Abstract

In summary, P2Y(2) R appears to be involved in asthmatic airway inflammation by mediating ATP-triggered migration of mDCs and eosinophils, as well as reactive oxygen species production. Together our data suggest that targeting P2Y(2) R might be a therapeutic option for the treatment of asthma.