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Plasma concentrations of lipid peroxidation products in children with acute leukaemia.
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2001
Year
Plasma ConcentrationsHematological MalignancyAcute LeukaemiaOncologyAllergyPediatric HematologyMalignant Blood DisorderLipid PeroxidationHematologyPediatricsPathologySerum Mda EstimationDisease ActivityMedicineLipid Peroxidation ProductsCancer ResearchOxidative Stress
Acute leukaemia is the most common childhood malignancy. The cause of leukaemia is not known in most of the cases and of late free radicals have been implicated in the pathogenesis of leukaemia. The degree of lipid peroxidation was studied in the present study as a marker of disease activity in 15 patients of acute lymphoblastic leukaemia and 20 healthy age and sex matched individuals served as control. Serum malonaldehyde (MDA) levels were increased in leukaemia and were higher in the active phase of disease as compared to those in remission, Hence, serum MDA estimation in leukaemia can be of help in diagnosis and to predict the chances of relapse.