A rare 8q24 single nucleotide polymorphism ( <scp>SNP</scp> ) predisposes <scp>N</scp> orth <scp>A</scp> merican men to prostate cancer and possibly more aggressive disease

Abstract

rs188140481[A] is a rare SNP that confers greater risk of prostate cancer compared with SNPs identified by genome-wide association studies. Because of its low frequency, larger studies are needed to validate the prognostic significance of this locus, and associations with adverse pathology.