NEW DEVELOPMENTS IN THE DIAGNOSIS AND TREATMENT OF PERNICIOUS ANEMIA

C. Lockard Conley, J. R. Krevans

Annals of Internal Medicine · 1955 · 27 citations · 18 references

Concepts

Abstract

Article1 October 1955NEW DEVELOPMENTS IN THE DIAGNOSIS AND TREATMENT OF PERNICIOUS ANEMIAC. LOCKARD CONLEY, M.D., JULIUS R. KREVANS, M.D.C. LOCKARD CONLEY, M.D., JULIUS R. KREVANS, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-4-758 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCriteria for the diagnosis of pernicious anemia must be reëvaluated in light of the changing pattern of this disease. The profound physical abnormalities and extreme hematologic aberrations associated with classic severe pernicious anemia are not often encountered in modern practice. There are two reasons for this alteration in the character of the disorder. In the first place, patients tend to consult their physicians early, at a time when symptoms may seem inconsequential. The only complaint may be slight weakness or fatigue, or perhaps soreness of the tongue. There may be no detectable pallor at this time, and even if the...Bibliography1. ConleyKrevans CLJR: Development of neurologic manifestations of pernicious anemia during multivitamin therapy, New England J. Med. 245: 529, 1951. CrossrefMedlineGoogle Scholar2. ChaietRosenblumWoodbury LCDT: Biosynthesis of radioactive vitamin B12 containing cobalt60 , Science 111: 601, 1950. CrossrefMedlineGoogle Scholar3. HeinleWelchScharfMeachamPrusoff RWADVGCWH: Studies of excretion (and absorption) of Co60-labelled vitamin B12 in pernicious anemia, Tr. A. Am. Physicians 65: 214, 1952. MedlineGoogle Scholar4. Meyer LM: Oral administration of Co60 vitamin B12 in pernicious anemia, Proc. Soc. Exper. Biol. and Med. 82: 490, 1953. CrossrefMedlineGoogle Scholar5. SwenseidHalstedLibby MEJARL: Excretion of cobalt60 labelled vitamin B12 after total gastrectomy, Proc. Soc. Exper. Biol. and Med. 83: 226, 1953. CrossrefMedlineGoogle Scholar6. CallenderTurnbullWakisaka STAG: Estimation of intrinsic factor of Castle by use of radioactive vitamin B12 , Brit. M. J. 1: 10, 1954. CrossrefMedlineGoogle Scholar7. KrevansConleySachs JRCLM: Influence of certain diseases on the absorption of vitamin B12 from the gastrointestinal tract, J. Clin. Investigation 33: 949, 1954. Google Scholar8. GlassBoydStephanson GBLJL: Intestinal absorption of vitamin B12 in humans as studied by isotope technic, Proc. Soc. Exper. Biol. and Med. 86: 522, 1954. CrossrefMedlineGoogle Scholar9. Schilling RF: Intrinsic factor studies. II. The effect of gastric juice on the urinary excretion of radioactivity after the oral administration of radioactive vitamin B12 , J. Lab. and Clin. Med. 42: 860, 1953. MedlineGoogle Scholar10. Owren PA: The deficiency of a factor necessary for normal protein synthesis in the liver in pernicious anemia, Proceedings of the Third International Congress of the International Society of Hematology, 1951, Grune and Stratton, New York, p. 34. Google Scholar11. BeardMcIlvanie MFSK: Vitamin B12 as a hemotherapeutic agent in pernicious anemia, Proceedings of the Third International Congress of the International Society of Hematology, 1951, Grune and Stratton, New York, p. 34. Google Scholar12. ConleyGreenHartmannKrevans CLTWRCJR: Prolonged treatment of pernicious anemia with vitamin B12 , Am. J. Med. 13: 284, 1952. CrossrefMedlineGoogle Scholar13. Ungley CC: Absorption of vitamin B12 in pernicious anemia. I. Oral administration without a source of intrinsic factor, Brit. M. J. 2: 905, 1950. CrossrefMedlineGoogle Scholar14. ConleyKrevansChowBarrowsLang CLJRBFCCA: Observations on the absorption, utilization and excretion of vitamin B12 , J. Lab. and Clin. Med. 38: 84, 1951. MedlineGoogle Scholar15. PitneyBeard WRMF: Serum and urine concentrations of vitamin B12 following oral administration of the vitamin, J. Clin. Nutrition 2: 89, 1954. CrossrefGoogle Scholar16. SpiesStoneLopezMilanesTocaAramburu TDREGGFRLT: Vitamin B12 by mouth in pernicious and nutritional macrocytic anaemia and sprue, Lancet 2: 454, 1949. CrossrefMedlineGoogle Scholar17. Hall BE: Studies on the nature of the intrinsic factor of Castle, Brit. M. J. 2: 585, 1950. CrossrefMedlineGoogle Scholar18. MeyerSawitskyCohenKrimFadem LMABSMR: Oral treatment of pernicious anemia with vitamin B12 , Am. J. M. Sc. 220: 604, 1950. CrossrefMedlineGoogle Scholar19. UnglaubGoldsmith WGGA: Oral vitamin B12 in the treatment of macrocytic anemias, South. M. J. 48: 261, 1955. CrossrefMedlineGoogle Scholar20. LearHarrisCastleFleming AAJWWBEM: The serum vitamin B12 concentration in pernicious anemia, J. Lab. and Clin. Med. 44: 715, 1954. MedlineGoogle Scholar21. RossMollinCoxUngley GIDLEVCC: Hematologic responses and concentration of vitamin B12 in serum and urine following oral administration of vitamin B12 without intrinsic factor, Blood 9: 473, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: C. LOCKARD CONLEY, M.D.; JULIUS R. KREVANS, M.D.Affiliations: Baltimore, Maryland*Presented at the Thirty-sixth Annual Session of The American College of Physicians, Philadelphia, Pennsylvania, April 27, 1955.From the Department of Medicine, the Johns Hopkins University and Hospital.†The original investigations described in this report were carried out under Contract AT (30-1) 1208 between the Atomic Energy Commission and the Johns Hopkins University, and were supported in part by grants from the National Vitamin Foundation and the Squibb Institute for Medical Research. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiencyEffective Treatment of Cobalamin Deficiency With Oral CobalaminEffective Treatment of Cobalamin Deficiency With Oral CobalaminDie megaloblastischen AnämienTHE INFLUENCE OF HOSPITAL FOOD ON THE FOLIC‐ACID STATUS OF LONG‐STAY ELDERLY PATIENTSORAL TREATMENT OF PERNICIOUS ANEMIA WITH HIGH DOSES OF VITAMIN B12 WITHOUT INTRINSIC FACTORAbsorption of vitamin B 12 from the intestineOral Vitamin B12 without Intrinsic Factor in the Treatment of Pernicious AnemiaS. O. WAIFE, M.D., F.A.C.P., C. J. JANSEN JR., M.D., R. E. CRABTREE, PH.D., E. L. GRINNAN, PH.D., P. J. FOUTS, M.D., F.A.C.P.Pernicious AnemiaHow Much Folic Acid Is Safe in Pernicious Anemia?Folic Acid Therapy and Spinal-Cord Degeneration in Pernicious AnemiaMieloses funiculares considerações a propósito de 110 casosPernicious Anemia Masked by a Multivitamin PreparationABSORPTION OF ORALLY ADMINISTERED VITAMIN B12 IN PERNICIOUS ANÆMIADELAYED DEVELOPMENT OF PERNICIOUS ANEMIA FOLLOWING GASTRECTOMY; HIGH FAMILIAL INCIDENCE OF CANCER: AN ILLUSTRATIVE CASE*MARTIN L. CHARLES, M.D., LOUIS J. VORHAUS, M.D.Treatment of megaloblastic anemiasThe Diagnosis and Treatment of Pernicious Anemia 1 October 1955Volume 43, Issue 4Page: 758-766KeywordsAnemiaAttentionFatigueFolic acidHospital medicineOral administrationPernicious anemiaTongue ePublished: 1 December 2008 Issue Published: 1 October 1955 PDF downloadLoading ...

References

18