Renal calcium phosphate and oxalate deposition in prolonged vitamin B ₆ deficiency: studies on a rat model of urolithiasis

Abstract

Histopathological and ultrastructural data indicate that a prolonged vitamin B6-deficient diet may contribute to the formation and deposition of calcium phosphate and oxalate crystals, which lead to severe damage of the renal parenchyma. This phenomenon may occur not only in growing rats, which have more active protein metabolism and consequently higher vitamin B6 requirements, but also in adult rats.