Effect of Water Extract of Germinated Brown Rice on Adiposity and Obesity Indices in Mice Fed a High Fat Diet

Abstract

An extract obtained from germinated brown rice was evaluated for protective effects against the adverse effects of a chronic high fat diet. C57BL6/J mice were divided into three groups; normal diet＋water group (ND), high fat diet＋water group (HD), high fat diet＋brown rice water extract group (HD＋BE) and fed for 8 weeks (6 day/week). The ND group diet was 11 kcal fat %. The HD group and HD＋BE group diet were 42 kcal fat %. Weight gains were not significantly different between groups. However, abdominal fat % was 1.6-fold higher in the HD group than HD＋BE group. Feed consumption was significantly higher in the ND group than HD group. Serum triglyceride, total cholesterol and LDL-cholesterol increased with a high fat diet, but decreased by brown rice water extract administration to the high fat diet group. Serum HDL-cholesterol decreased by the high fat diet, but increased by the brown rice water extract administration. Also, serum HDL-cholesterol/total cholesterol ratio was 2.3-fold higher in the HD＋BE than the HD. Liver triglyceride and total cholesterol were not significantly different among groups. These data suggest that brown rice water extract administration improves the serum lipid profiles of C57BL/6J mice.