Studies on Energy‐Linked Reactions

Abstract

The genetics of the two major phenotypic classes of oligomycin‐resistant yeast mutants have been investigated. All the class II mutants (oligomycin specific) tested show typical cytoplasmic inheritance and the determinants appear located on mtDNA. Evidence is presented that this type of resistance can be conferred by at least two distinct groups of nonallelic cytoplasmic determinants. The class I mutants which show cross resistance to a variety of inhibitors and uncouplers of energy conservation reactions exhibit behaviour on genetic analysis which is not fully understood. Tetrad analysis indicates that a nuclear gene is concerned but many anomalous observations, discussed here, suggestive of the involvement of a cytoplasmic element remain to be explained.