Cytochromes P-450 and the Activation and Inactivation of Mutagens and Carcinogens

Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for Detection

Bruce N. Ames, William E. Durston, Edith F. Yamasaki et al. · Proceedings of the National Academy of Sciences · 1973 · 2.3K citations · Full text

Pharmacy, Molecular Biology, Toxicology +17

Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or .beta.-naphthoflavone

F. Peter Guengerich, Ghazi A. Dannan, Stephen Wright et al. · Biochemistry · 1982 · 1K citations

Medicine, Biochemistry, Pharmacology +12

Role of Hemoprotein P-450 in Fatty Acid ω-Hydroxylation in a Soluble Enzyme System from Liver Microsomes

Albert Lu, M J Coon · Journal of Biological Chemistry · 1968 · 627 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Resolution of the Cytochrome P-450-containing ω-Hydroxylation System of Liver Microsomes into Three Components

Albert Lu, K.W. Junk, M J Coon · Journal of Biological Chemistry · 1969 · 579 citations · Full text

Medicine, Biochemistry, Pharmacology +15

Phosphatidylcholine Requirement in the Enzymatic Reduction of Hemoprotein P-450 and in Fatty Acid, Hydrocarbon, and Drug Hydroxylation

Henry W. Strobel, Anthony Y.H. Lu, Joanne K. Heidema et al. · Journal of Biological Chemistry · 1970 · 463 citations · Full text

Life Sciences, Biochemistry, Drug Metabolism +14