Contact System: A Vascular Biology Modulator With Anticoagulant, Profibrinolytic, Antiadhesive, and Proinflammatory Attributes

Abstract

physiologic reactions of vascular biology. Last, this presentation will point to possible new therapeutic strategies to treat HE KALLIKREIN-KININ system was first recognized as a plasma and tissue proteolytic system responsible for the liberation of the vasoactive, proinflammatory media-various diseases arising out of the knowledge of this system in physiologic and pathophysiologic states. tor, bradykinin (BK). 1 BK, a nonapeptide released from kininogens by kallikreins, could reproduce many of the charac-