Hyperphage: Improving Antibody Presentation in Phage Display

Abstract

Since its invention in the early 1990s, phage display has revolutionized the generation and engineering of monoclonal antibodies (for review, see ref. ). Without the need for laboratory animals or hybridomas, it was now possible to create antibodies binding to almost any antigen of choice. All this is accomplished in a system that completely by-passes our bodies immune system.