Selective attraction of eosinophils and synergism between eosinophil chemotactic factor of anaphylaxis (ECF-A) and a fragment cleaved from the fifth component of complement (C5a).

Abstract

ECF-A and C5a were chemotactic both for eosinophils and neutrophils. However, when eosinophils comprised approximately 10 per cent or more of a mixed leucocyte population, they were preferentially attracted by both of these agents. Marked synergism was observed between ECF-A and C5a in their ability to attract eosinophil leucocytes.