Evolution of cytochrome oxidase, an enzyme older than atmospheric oxygen.

The neighbor-joining method: a new method for reconstructing phylogenetic trees.

Naruya Saitou, M Nei · Molecular Biology and Evolution · 1987 · 60.5K citations · Full text

Life Sciences, Bioinformatics, Evolutionary Biology +17

A simple method for displaying the hydropathic character of a protein

Jack Kyte, Russell F. Doolittle · Journal of Molecular Biology · 1982 · 23.1K citations

Life Sciences, Biochemistry, Molecular Biology +12

A comprehensive set of sequence analysis programs for the VAX

John Devereux, Paul Haeberli, Oliver Smithies · Nucleic Acids Research · 1984 · 14.4K citations · Full text

Life Sciences, Bioinformatics, Genetics +8

Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya.

C R Woese, O. Kandler, Mark L. Wheelis · Proceedings of the National Academy of Sciences · 1990 · 6.1K citations

Life Sciences, Biology, Microbiology +11

Phylogenetic structure of the prokaryotic domain: The primary kingdoms

Carl R. Woese, George E. Fox · Proceedings of the National Academy of Sciences · 1977 · 4K citations · Full text

Life Sciences, Microbiology, Molecular Biology +17