Concepedia

The spliceosome is a therapeutic vulnerability in MYC-driven cancer

Tiffany Hsu, Lukas M. Simon, Nicholas J. Neill, Richard Marcotte, Azin Sayad, Christopher S. Bland, Gloria V. Echeverria, Tingting Sun, Sarah J. Kurley, Siddhartha Tyagi,

Nature · 2015 · 524 citations · 32 references

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32

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

John David Dignam, Russell M. Lebovitz, R G Roeder · Nucleic Acids Research · 1983 · 11.6K citations · Full text

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Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

Ji Luo, Nicole L. Solimini, Stephen J. Elledge · Cell · 2009 · 1.8K citations · Full text

, , +14

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

Charles Y. Lin, Jakob Lovén, Peter B. Rahl et al. · Cell · 2012 · 1.6K citations · Full text

, , +16

c-Myc Regulates Transcriptional Pause Release

Peter B. Rahl, Charles Y. Lin, Amy C. Seila et al. · Cell · 2010 · 1.3K citations · Full text

, , +12

Somatic<i>SF3B1</i>Mutation in Myelodysplasia with Ring Sideroblasts

Elli Papaemmanuil, Mario Cazzola, Jacqueline Boultwood et al. · New England Journal of Medicine · 2011 · 1.2K citations · Full text

, , +13