Serum Free Iron Concentration in Patients with Type 2 Diabetes Mellitus with Good and Poor Control and Its Correlation with Glycemic Control

Abstract

Diabetes mellitus (DM) co mprises a group of common metabolic disorders that share common phenotype of hyperglycemia. Understanding the pathogenesis and preventing long-term co mp licat ions have been major goals of research in diabetes mellitus. Emerging scientific evidences has disclosed unsuspected influence between iron metabolism and type 2 Diabetes mellitus. Present study was undertaken to assess level of seru m free iron concentration in type 2 Diabetes mellitus patients with good and poor glycemic control and find out correlation between serum free iron concentrations with glycemic control. A cross sectional study consists of 150 patients out of them 50 patients having type 2 DM with good control (Group II), 50 patients with type 2 DM with poor control (Group III) and 50 normal healthy control (Group-I) were selected. Statistically significant increase in free iron concentration in group III cases compare to Group I and Group II. There was a statically significant positive correlat ion between free iron concentration and FBS, PP2BS and Glycated Hemoglobin. In conclusion, Serum free iron concentration was higher in patients with type 2 diabetes mellitus with poor control. A lso there was a positive correlat ion with seru m free iron concentration and glycemic control. These suggest important ro le of iron in metabolic derangement in diabetic patients and its complications.