Concepedia

Multimodal Imaging of Orthotopic Mouse Model of Endometrial Carcinoma

Ingfrid S. Haldorsen, Mihaela Popa, Tina Fonnes, Njål Brekke, Reidun Kristin Kopperud, Nicole C.M. Visser, Cecilie Brekke Rygh, Tina Pavlin, Helga B. Salvesen, Emmet McCormack,

PLoS ONE · 2015 · 40 citations · 14 references

DOIFull text

Open access

Abstract

We demonstrate that all imaging modalities enable monitoring of tumour growth and metastatic spread in an orthotopic mouse model of endometrial carcinoma. Both PET tracers, 18F-FDG and 18F-FLT, appear to be equally feasible for detecting tumour development and represent, together with MRI, promising imaging tools for monitoring of patient-derived xenograft (PDX) cancer models.

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14

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