Pluronic P85 Increases Permeability of a Broad Spectrum of Drugs in Polarized BBMEC and Caco-2 Cell Monolayers

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

Carlos Cordon‐Cardo, James P. O’Brien, D Casals et al. · Proceedings of the National Academy of Sciences · 1989 · 1.7K citations · Full text

Medicine, Oncology, Pharmacology +16

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

Alfred H. Schinkel, Els Wagenaar, Carla A.A.M. Mol et al. · Journal of Clinical Investigation · 1996 · 1.3K citations · Full text

Medicine, Pharmacokinetics, Pharmacology +15

Hypersensitization of Multidrug Resistant Human Ovarian Carcinoma Cells by Pluronic P85 Block Copolymer

Valery Yu. Alakhov, E. Yu. Moskaleva, Elena V. Batrakova et al. · Bioconjugate Chemistry · 1996 · 305 citations

Medicine, Oncology, Pharmacology +14

Hypersensitizing effect of pluronic L61 on cytotoxic activity, transport, and subcellular distribution of doxorubicin in multiple drug-resistant cells.

Annie Venne, S Li, Rosemonde Mandeville et al. · PubMed · 1996 · 226 citations

Medicine, Oncology, Pharmacology +17

Anthracycline antibiotics non-covalently incorporated into the block copolymer micelles: in vivo evaluation of anti-cancer activity

EV Batrakova, T.Yu. Dorodnych, EY Klinskii et al. · British Journal of Cancer · 1996 · 226 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17