Concepedia

Steady-State Kinetics and Dynamics of Morphine in Cancer Patients

Lona Louring Christrup, Per Sjøgren, Niels‐Henrik Jensen, Karsten Elbæk, Annette Kjær Ersbøll

Journal of Pain and Symptom Management · 1999 · 17 citations · 36 references

Open access

Concepts

PharmacyPharmacokineticsPharmacologyCancer PharmacologyMedical OncologyPharmacokinetic ModelingDrug Distribution KineticsDrug Half-lifeKinetic ModelingPharmacodynamics Of Anticancer DrugsPharmacokinetics Of Anticancer DrugsTime-dependent KineticsConcentration-time Curve CharacterizationPre-steady-state KineticsSteady-state Half-lifeSteady-state KineticsTissue Distribution Kinetics

References

36

Cross-Over Trials in Clinical Research

Technometrics · 1994 · 765 citations

Public Health, Biostatistics, Experimental Design +11

Morphine and metabolite behavior after different routes of morphine administration: Demonstration of the importance of the active metabolite morphine-6-glucuronide

Richard H. Osborne, Simon Joel, Duncan Trew et al. · Clinical Pharmacology & Therapeutics · 1990 · 448 citations

Medicine, Pharmacokinetics, Pharmacology +15

Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite.

Dennis Paúl, Kelly M. Standifer, Charles E. Inturrisi et al. · Journal of Pharmacology and Experimental Therapeutics · 1989 · 395 citations

Medicine, Medicinal Chemistry, Pharmacology +15

The analgesic activity of morphine‐6‐glucuronide.

Richard H. Osborne, P.I. Thompson, S Joel et al. · British Journal of Clinical Pharmacology · 1992 · 275 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +16

Broad-spectrum Redefined

A E HUGH, J A FOX · The Lancet · 1963 · 260 citations