Effects of Flavonoids in Morus indica on Blood Lipids and Glucose in Hyperlipidemia-diabetic Rats

Abstract

Abstract Objective To investigate the effect and possible mechanism of flavonoids extracted from Morus indica (FMI) on blood lipids and glucose. Methods The experimental hyperlipidemia-diabetic rats were induced by high-fat diet (HFD) and low dose of Streptozotocin (STZ). Flavonoids-treated rats were pretreated with FMI (50, 100, and 200 mg/kg). The plasma, skeletal muscle, and livers were isolated for biochemical assays, HE staining, immunohistochemistry, and Western blotting analysis. Results The results showed that the body weight in flavonoidstreated (100 and 200 mg/kg) rats was reduced ( P P P P P P P Conclusion The above results demonstrate that the effect of FMI is related to its up-regulation of hepatic SOD activity, reduction of hepatic MDA content, down-regulation of hepatic CYP2E1 expression, and increase of GLUT-4 expression in skeletal muscle, which suggests that FMI may prevent or improve hyperlipidemia and hyperglycemia caused by an excessive HFD.