Study of Povidone Iodine Loaded Hydrogels as Wound Dressing Material

Abstract

Hydrogel wound dressing can protect injured skin and keep the wound surface appropriately moist to speed up the healing process by absorbing exudates. Hydrogels of caboxymethyl cellulose (CMC)/ poly (vinyl alcohol) (PVA)/gelatin and crosslinked polyacrylamide (PAM) were prepared. The prepared hydrogels was loaded with Povidone-iodine for using as wound dressing. Release and swelling characteristics were also studied for loaded hydrogels and found to be dependent on chemical architecture. Blood compatibility was also studied by clot formation and haemolysis assay. Dispersion characteristics of gels were also observed in Phosphate buffer saline (PBS). The prepared hydrogels used as wound dressing on mice as an animal model. The prepared wound dressing was found to be biocompatible and not cause any inflammation on mice skin. © Society for Biomaterials and Artificial Organs (India), 20090324-39.