Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): a double-blind, randomised, placebo-controlled, parallel-group, multinational, multicentre phase 3a trial

Christopher Sorli, Shin‐ichi Harashima, George Tsoukas, +4

The Lancet Diabetes & Endocrinology

Diabetes ManagementSustain 1DiabetesType 2Clinical Trials +5

Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans

Caroline J. Breitbach, James M. Burke, Derek J. Jonker, +21

Nature

Molecular VirologyViral PathogenesisImmunologyVirologyIntravenous Delivery +4

Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers

Dena Marrinucci, Kelly Bethel, Anand Kolatkar, +21

Physical Biology

A Phase I Study of Telomerase-specific Replication Competent Oncolytic Adenovirus (Telomelysin) for Various Solid Tumors

John Nemunaitis, Alex W. Tong, Michael Nemunaitis, +12

Molecular Therapy

A First in Human Phase 1 Study of CG0070, a GM-CSF Expressing Oncolytic Adenovirus, for the Treatment of Nonmuscle Invasive Bladder Cancer

James M. Burke, Donald L. Lamm, Maxwell V. Meng, +9

The Journal of Urology

How complexity science can inform scale-up and spread in health care: Understanding the role of self-organization in variation across local contexts

Holly J. Lanham, Luci K. Leykum, Barbara S. Taylor, +3

Social Science & Medicine

NursingFamily MedicineIntegrated CarePrimary CareComplex Adaptive System +4

Characterization of circulating tumor cell aggregates identified in patients with epithelial tumors

Edward H. Cho, Marco Wendel, Madelyn Luttgen, +12

Physical Biology

Biological MicroenvironmentsPathologyCtc AggregationCancer BiologyTumor Biology +16

Lenalidomide and high-dose dexamethasone compared with dexamethasone as initial therapy for multiple myeloma: a randomized Southwest Oncology Group trial (S0232)

Jeffrey A. Zonder, John Crowley, Mohamad A. Hussein, +6

Blood

The effect of treatment time in locally advanced cervical cancer in the era of concurrent chemoradiotherapy

Suisui Song, Sonali Rudra, Michael D. Hasselle, +6

Cancer

A Mechanistic Proof-of-concept Clinical Trial With JX-594, a Targeted Multi-mechanistic Oncolytic Poxvirus, in Patients With Metastatic Melanoma

Tae-Ho Hwang, Anne Moon, James M. Burke, +11

Molecular Therapy