Neoleukin Therapeutics (United States)

De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2

Thomas W. Linsky, Renan Vergara, Jorgen Nelson et al. · Science · 2020 · 207 citations · Full text

Viral Replication, Spike Protein, Synthetic Virology +14

Atrasentan in Patients with IgA Nephropathy

Hiddo J.L. Heerspink, Meg Jardine, Donald E. Kohan et al. · New England Journal of Medicine · 2024 · 68 citations

The minimally important difference and patient acceptable symptom state for the Raynaud's condition score in patients with Raynaud's phenomenon in a large randomised controlled clinical trial

Puja Khanna, Paul Maranian, Jeff Gregory et al. · Annals of the Rheumatic Diseases · 2009 · 65 citations · Full text

Substrate specificity of lysophosphatidic acid acyltransferase β—evidence from membrane and whole cell assays

David Hollenback, Lynn Bonham, Laura Law et al. · Journal of Lipid Research · 2005 · 59 citations · Full text

Proteinlipid Interaction, Lpaat-beta Activity, Cellular Enzymology +14

The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity

Mark Maurer, Katherine E. Lewis, Joseph L. Kuijper et al. · Nature Communications · 2022 · 57 citations · Full text

Increased Pd-l1 Affinity, Immunology, Anti-tumor Immunity +16