Casma Therapeutics (United States)

Caveolae-Mediated Endocytosis as a Novel Mechanism of Resistance to Trastuzumab Emtansine (T-DM1)

Matthew Sung, Xingzhi Tan, Bingwen Lu et al. · Molecular Cancer Therapeutics · 2017 · 208 citations

Medicine, Oncology, Pharmacology +17

V-ATPase is a universal regulator of LC3-associated phagocytosis and non-canonical autophagy

Kirsty M. Hooper, Élise Jacquin, Taoyingnan Li et al. · The Journal of Cell Biology · 2022 · 171 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13

Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase

Justin T. Ernst, Peggy A. Thompson, Christian Nilewski et al. · Journal of Medicinal Chemistry · 2020 · 145 citations · Full text

Life Sciences, Oncology, Pharmacology +16

GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis

Jonathan M. Goodwin, Ward G. Walkup, Kirsty M. Hooper et al. · Science Advances · 2021 · 126 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Genome-Scale CRISPR Screens Identify Human Pluripotency-Specific Genes

Robert J. Ihry, Max R. Salick, Daniel Ho et al. · Cell Reports · 2019 · 80 citations · Full text

Life Sciences, Genetics, Molecular Biology +17