Centre Hospitalier René-Dubos

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

J-Y Douillard, David Cunningham, AD Roth et al. · The Lancet · 2000 · 3.3K citations

Medicine, Pharmacology, Colorectal Cancer +6

Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit

Stéphane Gaudry, David Hajage, Frédérique Schortgen et al. · New England Journal of Medicine · 2016 · 1.2K citations · Full text

Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial

Christophe Le Tourneau, Jean-Pierre Delord, Anthony Gonçalvès et al. · The Lancet Oncology · 2015 · 1.1K citations

Advanced Cancer, Drug Targeting, Oncology +12

Churg-Strauss Syndrome Clinical Study and Long-Term Follow-Up of 96 Patients

Pascal Cohen, M. Gayraud, François Lhote et al. · Medicine · 1999 · 1.1K citations

Asthma, Vasculitis, Immunology +19

Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trial

Martin Reck, R. Kaiser, Anders Mellemgaard et al. · The Lancet Oncology · 2014 · 931 citations · Full text

Oncology, Nintedanib Versus Docetaxel, Lume-lung 1 +10