Olatec (United States)

OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation

Carlo Marchetti, Benjamin J. Swartzwelter, Fabia Gamboni et al. · Proceedings of the National Academy of Sciences · 2018 · 520 citations · Full text

The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer’s disease

Niklas Lonnemann, Shirin Hosseini, Carlo Marchetti et al. · Proceedings of the National Academy of Sciences · 2020 · 269 citations · Full text

Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial

Viola Klück, Tim Jansen, M. Janssen et al. · The Lancet Rheumatology · 2020 · 257 citations · Full text

Anti-inflammatory, Gouty Arthritis, Pharmacology +8

OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis

Alba Sánchez‐Fernández, Damaris B. Skouras, Charles A. Dinarello et al. · Frontiers in Immunology · 2019 · 152 citations · Full text

Inhibition of the NLRP3 inflammasome by OLT1177 induces functional protection and myelin preservation after spinal cord injury

Jesús Amo‐Aparicio, Joana Garcia-Garcia, María Puigdomenech et al. · Experimental Neurology · 2021 · 35 citations

Inflammation, Neuroregeneration, Spinal Cord Injury +12