Arytha Biosciences (United States)

Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation

Annette Ives, Johji Nomura, Fabio Martinon et al. · Nature Communications · 2015 · 265 citations · Full text

Life Sciences, Cell Biology, Immunology +17

Lesinurad, a Selective Uric Acid Reabsorption Inhibitor, in Combination With Febuxostat in Patients With Tophaceous Gout: Findings of a Phase III Clinical Trial

Nicola Dalbeth, Graeme Jones, Robert Terkeltaub et al. · Arthritis & Rheumatology · 2017 · 151 citations · Full text

Pharmacy, Pharmacotherapy, Drug Repurposing +13

3D Proximal Tubule Tissues Recapitulate Key Aspects of Renal Physiology to Enable Nephrotoxicity Testing

Shelby M. King, J. William Higgins, Celina Nino et al. · Frontiers in Physiology · 2017 · 122 citations · Full text

Medicine, Nephrology, Pharmacology +17

Multicenter Phase I Trial of the Mitogen-Activated Protein Kinase 1/2 Inhibitor BAY 86-9766 in Patients with Advanced Cancer

Colin D. Weekes, Daniel D. Von Hoff, Alex A. Adjei et al. · Clinical Cancer Research · 2013 · 60 citations · Full text

Medicine, Oncology, Pharmacology +17

Phase 2a Randomized Controlled Trial of Short-Term Activity, Safety, and Pharmacokinetics of a Novel Nonnucleoside Reverse Transcriptase Inhibitor, RDEA806, in HIV-1-Positive, Antiretroviral-Naive Subjects

Graeme Moyle, Marta Boffito, Albrecht Stoehr et al. · Antimicrobial Agents and Chemotherapy · 2010 · 41 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17