Kimberly J. Manhard

Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney

Jeffrey N. Miner, Philip K. Tan, David Hyndman et al. · Arthritis Research & Therapy · 2016 · 124 citations · Full text

Pharmacy, Pharmacology, Pharmacotherapy +17

Pharmacodynamic, pharmacokinetic and tolerability evaluation of concomitant administration of lesinurad and febuxostat in gout patients with hyperuricaemia

R. Fleischmann, Bradley M. Kerr, Li‐Tain Yeh et al. · Lara D. Veeken · 2014 · 104 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +15

Pharmacokinetics, pharmacodynamics, and safety of lesinurad, a selective uric acid reabsorption inhibitor, in healthy adult males

Zancong Shen, Colin Rowlings, Brad Kerr et al. · Drug Design Development and Therapy · 2015 · 55 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +16

Phase 2a Randomized Controlled Trial of Short-Term Activity, Safety, and Pharmacokinetics of a Novel Nonnucleoside Reverse Transcriptase Inhibitor, RDEA806, in HIV-1-Positive, Antiretroviral-Naive Subjects

Graeme Moyle, Marta Boffito, Albrecht Stoehr et al. · Antimicrobial Agents and Chemotherapy · 2010 · 41 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

A Phase I Study of the Safety, Pharmacokinetics, and Pharmacodynamics of Combination Therapy with Refametinib plus Sorafenib in Patients with Advanced Cancer

Alex A. Adjei, Donald Richards, Anthony B. El-Khoueiry et al. · Clinical Cancer Research · 2015 · 22 citations · Full text

Medicine, Oncology, Pharmacology +16