Innovation Pathways

Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction

Vladimir V. Senatorov, Aaron R. Friedman, Dan Z. Milikovsky et al. · Science Translational Medicine · 2019 · 257 citations

Medicine, Neurobiology, Neuroscience +17

IPW-5371 Proves Effective as a Radiation Countermeasure by Mitigating Radiation-Induced Late Effects

Christopher S. Rabender, Eleonora Mezzaroma, Adolfo G Mauro et al. · Radiation Research · 2016 · 42 citations · Full text

Medicine, Cardiology, Pharmacotherapy +17

Rat Models of Partial-body Irradiation with Bone Marrow-sparing (Leg-out PBI) Designed for FDA Approval of Countermeasures for Mitigation of Acute and Delayed Injuries by Radiation

Brian L. Fish, Thomas J. MacVittie, Feng Gao et al. · Health Physics · 2021 · 40 citations · Full text

Medicine, Hematology, Radiation Oncology +17

Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3

Jeremiah P. Malerich, Jennifer S. Lam, Barry Hart et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

3-Heterocyclyl quinolone inhibitors of the HCV NS5B polymerase

Dange V. Kumar, Roopa Rai, Ken A. Brameld et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 17 citations

Life Sciences, Medicinal Chemistry, Pharmacology +14