Samaritan Pharmaceuticals (United States)

Beta-Amyloid and Oxidative Stress Jointly Induce Neuronal Death, Amyloid Deposits, Gliosis, and Memory Impairment in the Rat Brain

Laurent Lecanu, Janet Greeson, Vassilios Papadopoulos · Pharmacology · 2005 · 58 citations

Memory Impairment, Abeta42-independent Oxidative Stress, Cell Death +18

Identification of naturally occurring spirostenols preventing β-amyloid-induced neurotoxicity

Laurent Lecanu, Wenguo Yao, Gary Teper et al. · Steroids · 2003 · 49 citations

Medicine, Protein Misfolding, Neuroprotection +2

22<i>R</i>‐Hydroxycholesterol protects neuronal cells from β‐amyloid‐induced cytotoxicity by binding to β‐amyloid peptide

Zhixing Yao, Rachel C. Brown, Gary Teper et al. · Journal of Neurochemistry · 2002 · 47 citations

Neurodegenerative Diseases, Alzheimer's Disease, Oxysterol +15

The spirostenol (22R, 25R)-20α-spirost-5-en-3β-yl hexanoate blocks mitochondrial uptake of Aβ in neuronal cells and prevents Aβ-induced impairment of mitochondrial function

Laurent Tillement, Laurent Lecanu, Wenguo Yao et al. · Steroids · 2006 · 46 citations

Oxysterol, Biochemistry, Mitochondrial Function +9

3D QSAR studies of AChE inhibitors based on molecular docking scores and CoMFA

Nagaraju Akula, Laurent Lecanu, Janet Greeson et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 42 citations

Molecular Docking, Qsar Studies, Medicinal Chemistry +10