ManRos Therapeutics (France)

The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome

Marion Delous, Lekbir Baala, Rémi Salomon et al. · Nature Genetics · 2007 · 489 citations

Cerebello-oculo-renal Syndrome, Ciliary Gene Rpgrip1l, Developmental Biology +9

Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B

Tania Tahtouh, Jonathan M. Elkins, P. Filippakopoulos et al. · Journal of Medicinal Chemistry · 2012 · 184 citations · Full text

Dual Specificity, Drug Target, Kinase Inhibitors +21

Isolation of drugs active against mammalian prions using a yeast-based screening assay

Stéphane Bach, Nicolas Talarek, Thibault Andrieu et al. · Nature Biotechnology · 2003 · 175 citations · Full text

Biochemistry, Medicine, Natural Sciences +8

The very low penetrance of cystic fibrosis for the R117H mutation: a reappraisal for genetic counselling and newborn screening

Christel Thauvin‐Robinet, À. Munck, Frédéric Huet et al. · Journal of Medical Genetics · 2009 · 126 citations · Full text

10-Iodo-11<i>H</i>-indolo[3,2-<i>c</i>]quinoline-6-carboxylic Acids Are Selective Inhibitors of DYRK1A

Hannes Falke, A. Chaikuad, Anja Becker et al. · Journal of Medicinal Chemistry · 2015 · 98 citations · Full text